Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA

U3 snoRNA and the associated Rrp9/U3-55K protein are essential for 18S rRNA production by the SSU-processome complex. U3 and Rrp9 are required for early pre-rRNA cleavages at sites A0, A1 and A2, but the mechanism remains unclear. Substitution of Arg 289 in Rrp9 to Ala (R289A) specifically reduced c...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Clerget, Guillaume, Bourguignon-Igel, Valérie, Marmier-Gourrier, Nathalie, Rolland, Nicolas, Wacheul, Ludivine, Manival, Xavier, Charron, Christophe, Kufel, Joanna, Méreau, Agnès, Senty-Ségault, Véronique, Tollervey, David, Lafontaine, Denis L J, Branlant, Christiane, Rederstorff, Mathieu
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144924/
https://ncbi.nlm.nih.gov/pubmed/31996908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa066
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