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Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated 5-IP7 promotes insulin secretion from pancrea...
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| Publicado no: | Molecules |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7144392/ https://ncbi.nlm.nih.gov/pubmed/32204420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25061403 |
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