Comparisons of In Vivo and In Vitro Opioid Effects of Newly Synthesized 14-Methoxycodeine-6-O-sulfate and Codeine-6-O-sulfate

The present work represents the in vitro (potency, affinity, efficacy) and in vivo (antinociception, constipation) opioid pharmacology of the novel compound 14-methoxycodeine-6-O-sulfate (14-OMeC6SU), compared to the reference compounds codeine-6-O-sulfate (C6SU), codeine and morphine. Based on in v...

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Publicado no:Molecules
Main Authors: Zádor, Ferenc, Mohammadzadeh, Amir, Balogh, Mihály, Zádori, Zoltán S., Király, Kornél, Barsi, Szilvia, Galambos, Anna Rita, László, Szilvia B., Hutka, Barbara, Váradi, András, Hosztafi, Sándor, Riba, Pál, Benyhe, Sándor, Fürst, Susanna, Al-Khrasani, Mahmoud
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144380/
https://ncbi.nlm.nih.gov/pubmed/32192229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25061370
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