Monomerization of ALK Fusion Proteins as a Therapeutic Strategy in ALK-Rearranged Non-small Cell Lung Cancers

Objective: Oncogenic echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) (EML4-ALK) fusion proteins found in non-small cell lung cancers (NSCLC) are constitutively phosphorylated and activated by dimerization via the coiled-coil domain (cc) within EML4. Here, we...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Hirai, Noriko, Sasaki, Takaaki, Okumura, Shunsuke, Minami, Yoshinori, Chiba, Shinichi, Ohsaki, Yoshinobu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142238/
https://ncbi.nlm.nih.gov/pubmed/32300555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00419
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