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Ospemifene displays broad-spectrum synergistic interactions with itraconazole through potent interference with fungal efflux activities

Azole antifungals are vital therapeutic options for treating invasive mycotic infections. However, the emergence of azole-resistant isolates combined with limited therapeutic options presents a growing challenge in medical mycology. To address this issue, we utilized microdilution checkerboard assay...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Eldesouky, Hassan E., Salama, Ehab A., Hazbun, Tony R., Mayhoub, Abdelrahman S., Seleem, Mohamed N.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142066/
https://ncbi.nlm.nih.gov/pubmed/32269301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62976-y
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