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Optogenetic Rac1 engineered from membrane lipid-binding RGS-LOV for inducible lamellipodia formation
We report the construction of a single-component optogenetic Rac1 (opto-Rac1) to control actin polymerization by dynamic membrane recruitment. Opto-Rac1 is a fusion of wildtype human Rac1 small GTPase to the C-terminal region of BcLOV4, a LOV (light-oxygen-voltage) photoreceptor that rapidly binds t...
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| 發表在: | Photochem Photobiol Sci |
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| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7141788/ https://ncbi.nlm.nih.gov/pubmed/32048687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9pp00434c |
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