Metabolic reprograming of LPS-stimulated human lung macrophages involves tryptophan metabolism and the aspartate-arginosuccinate shunt

Lung macrophages (LM) are in the first line of defense against inhaled pathogens and can undergo phenotypic polarization to the proinflammatory M1 after stimulation with Toll-like receptor agonists. The objective of the present work was to characterize the metabolic alterations occurring during the...

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Udgivet i:PLoS One
Main Authors: Fall, Fanta, Lamy, Elodie, Brollo, Marion, Naline, Emmanuel, Lenuzza, Natacha, Thévenot, Etienne, Devillier, Philippe, Grassin-Delyle, Stanislas
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141605/
https://ncbi.nlm.nih.gov/pubmed/32267860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0230813
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