Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma

Resistance to radiotherapy (IR), with consequent disease recurrence, continues to limit the efficacy of contemporary anticancer treatment for patients with hepatocellular carcinoma (HCC), especially in late stage. Despite accruing evidence implicating the PI3K/AKT signaling pathway in cancer-promoti...

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Опубликовано в: :Cells
Главные авторы: Bamodu, Oluwaseun Adebayo, Chang, Hang-Lung, Ong, Jiann-Ruey, Lee, Wei-Hwa, Yeh, Chi-Tai, Tsai, Jo-Ting
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140693/
https://ncbi.nlm.nih.gov/pubmed/32197467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9030746
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