A Potential Role of RUNX2- RUNT Domain in Modulating the Expression of Genes Involved in Bone Metastases: An In Vitro Study with Melanoma Cells

Ectopic expression of RUNX2 has been reported in several tumors. In melanoma cells, the RUNT domain of RUNX2 increases cell proliferation and migration. Due to the strong link between RUNX2 and skeletal development, we hypothesized that the RUNT domain may be involved in the modulation of mechanisms...

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Veröffentlicht in:Cells
Hauptverfasser: Deiana, Michela, Dalle Carbonare, Luca, Serena, Michela, Cheri, Samuele, Mutascio, Simona, Gandini, Alberto, Innamorati, Giulio, Lorenzi, Pamela, Cumerlato, Michela, Bertacco, Jessica, Antoniazzi, Franco, Romanelli, Maria Grazia, Mottes, Monica, Zipeto, Donato, Valenti, Maria Teresa
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140624/
https://ncbi.nlm.nih.gov/pubmed/32204402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9030751
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