Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection

Human RNASET2 acts as a powerful oncosuppressor protein in in vivo xenograft-based murine models of human cancer. Secretion of RNASET2 in the tumor microenvironment seems involved in tumor suppression, following recruitment of M1-polarized macrophages. Here, we report a murine Rnaset2-based syngenei...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: De Vito, Annarosaria, Orecchia, Paola, Balza, Enrica, Reverberi, Daniele, Scaldaferri, Debora, Taramelli, Roberto, Noonan, Douglas M., Acquati, Francesco, Mortara, Lorenzo
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140044/
https://ncbi.nlm.nih.gov/pubmed/32197460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030717
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