Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer

Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45(+) immune cell density adjacent to E-selectin expressing inflamed vessels in doxorubicin (DOX)-treated residual...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Morita, Yoshihiro, Leslie, Macall, Kameyama, Hiroyasu, Lokesh, Ganesh L. R., Ichimura, Norihisa, Davis, Rachel, Hills, Natalie, Hasan, Nafis, Zhang, Roy, Kondo, Yuji, Gorenstein, David G., Volk, David E., Chervoneva, Inna, Rui, Hallgeir, Tanaka, Takemi
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140021/
https://ncbi.nlm.nih.gov/pubmed/32204492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030725
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