Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts

The sphingosine kinase 1 (SPHK1)/sphingosine–1–phosphate (S1P) signaling axis is emerging as a key player in the development of idiopathic pulmonary fibrosis (IPF) and bleomycin (BLM)-induced lung fibrosis in mice. Recent evidence implicates the involvement of the Hippo/Yes-associated protein (YAP)...

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Udgivet i:Int J Mol Sci
Main Authors: Huang, Long Shuang, Sudhadevi, Tara, Fu, Panfeng, Punathil-Kannan, Prasanth-Kumar, Ebenezer, David Lenin, Ramchandran, Ramaswamy, Putherickal, Vijay, Cheresh, Paul, Zhou, Guofei, Ha, Alison W., Harijith, Anantha, Kamp, David W., Natarajan, Viswanathan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7139883/
https://ncbi.nlm.nih.gov/pubmed/32192225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21062064
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