Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer’s disease

INTRODUCTION: We investigated plasma proteomic markers of astrocytopathy, brain degeneration, plasticity, and inflammation in sporadic early-onset versus late-onset Alzheimer’s disease (EOAD and LOAD). METHODS: Plasma was analyzed using ultra-sensitive immuno-based assays from 33 EOAD, 30 LOAD, and...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement
Principais autores: Elahi, Fanny M., Casaletto, Kaitlin B., La Joie, Renaud, Walters, Samantha M., Harvey, Danielle, Wolf, Amy, Edwards, Lauren, Rivera-Contreras, Wilfredo, Karydas, Anna, Cobigo, Yann, Rosen, Howard J., DeCarli, Charles, Miller, Bruce L., Rabinovici, Gil D., Kramer, Joel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138729/
https://ncbi.nlm.nih.gov/pubmed/31879236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2019.09.004
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