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Celluar Folding Determinants and Conformational Plasticity of Native C-Reactive Protein

C-reactive protein (CRP) is an acute phase reactant secreted by hepatocytes as a pentamer. The structure formation of pentameric CRP has been demonstrated to proceed in a stepwise manner in live cells. Here, we further dissect the sequence determinants that underlie the key steps in cellular folding...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lv, Jian-Min, Chen, Jun-Yao, Liu, Zu-Pei, Yao, Zhen-Yu, Wu, Yue-Xin, Tong, Cheng-Sen, Cheng, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7137756/
https://ncbi.nlm.nih.gov/pubmed/32296446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00583
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