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Generation of intestinal organoids derived from human pluripotent stem cells for drug testing

Drug absorption via the intestinal tissue is modulated by membrane permeability and metabolism in intestinal epithelial cells (IECs). In drug discovery research, using human IECs to evaluate membrane permeability and metabolic stability can offer very useful information when exploring for drug candi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Yoshida, Shinpei, Miwa, Hiroto, Kawachi, Tomoyuki, Kume, Shoen, Takahashi, Koji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136241/
https://ncbi.nlm.nih.gov/pubmed/32249832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63151-z
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