Centenarian Exomes as a Tool for Evaluating the Clinical Relevance of Germline Tumor Suppressor Mutations

OBJECTIVES: The aim of the present study was to evaluate the clinical relevance of mutations in tumor suppressor genes using whole-exome sequencing data from centenarians and young healthy individuals. METHODS: Two pools, one of centenarians and one of young individuals, were constructed and whole-e...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Technol Cancer Res Treat
Main Authors: Balabanski, Lubomir, Serbezov, Dimitar, Nikolova, Dragomira, Antonova, Olga, Nesheva, Desislava, Hammoudeh, Zora, Vazharova, Radoslava, Karachanak-Yankova, Sena, Staneva, Rada, Mihaylova, Marta, Damyanova, Vera, Hadjidekova, Savina, Toncheva, Draga
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2020
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132786/
https://ncbi.nlm.nih.gov/pubmed/32233832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1533033820911082
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