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Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo

The N-degron pathway is an emerging target for anti-tumor therapies, because of its capacity to positively regulate many hallmarks of cancer, including angiogenesis, cell proliferation, motility, and survival. Thus, inhibition of the N-degron pathway offers the potential to be a highly effective ant...

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Publicado en:Mol Ther
Autores principales: Leboeuf, Dominique, Abakumova, Tatiana, Prikazchikova, Tatiana, Rhym, Luke, Anderson, Daniel G., Zatsepin, Timofei S., Piatkov, Konstantin I.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132617/
https://ncbi.nlm.nih.gov/pubmed/32087767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.01.021
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