A dual blocker of endothelin A/B receptors mitigates hypertension but not renal dysfunction in a rat model of chronic kidney disease and sleep apnea

Obstructive sleep apnea is characterized by recurrent episodes of pharyngeal collapse during sleep, resulting in intermittent hypoxia (IH), and is associated with a high incidence of hypertension and accelerated renal failure. In rodents, endothelin (ET)-1 contributes to IH-induced hypertension, and...

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Morales-Loredo, Humberto, Jones, David, Barrera, Adelaeda, Mendiola, Perenkita J., Garcia, Joshua, Pace, Carolyn, Murphy, Minerva, Kanagy, Nancy L., Gonzalez Bosc, Laura V.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132313/
https://ncbi.nlm.nih.gov/pubmed/30810064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00018.2019
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