Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6(+)B helper T cells in systemic lupus erythematosus

Interleukin 10 (IL-10) is an antiinflammatory cytokine, but also promotes B cell responses and plays a pathogenic role in systemic lupus erythematosus (SLE). CD4(+)CCR6(+)IL-7R(+)T cells from human tonsils produced IL-10 following stimulation by naïve B cells, which promoted B cell immunoglobulin G...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Facciotti, F., Larghi, P., Bosotti, R., Vasco, C., Gagliani, N., Cordiglieri, C., Mazzara, S., Ranzani, V., Rottoli, E., Curti, S., Penatti, A., Karnani, B., Kobayashi, Y., Crosti, M., Bombaci, M., van Hamburg, J. P., Rossetti, G., Gualtierotti, R., Gerosa, M., Gatti, S., Torretta, S., Pignataro, L., Tas, S. W., Abrignani, S., Pagani, M., Grassi, F., Meroni, P. L., Flavell, R. A., Geginat, J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132288/
https://ncbi.nlm.nih.gov/pubmed/32184325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917834117
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