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Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6(+)B helper T cells in systemic lupus erythematosus
Interleukin 10 (IL-10) is an antiinflammatory cytokine, but also promotes B cell responses and plays a pathogenic role in systemic lupus erythematosus (SLE). CD4(+)CCR6(+)IL-7R(+)T cells from human tonsils produced IL-10 following stimulation by naïve B cells, which promoted B cell immunoglobulin G...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7132288/ https://ncbi.nlm.nih.gov/pubmed/32184325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917834117 |
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