Vedolizumab in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Safety, Efficacy, and Place of Therapy

INTRODUCTION: Selective blockade of the integrins and mucosal adhesion molecules is a promising therapeutic strategy for ulcerative colitis (UC). Vedolizumab (VDZ), a humanized IgG1 monoclonal antibody against α4β7 integrin, selectively blocks the trafficking of the leukocytes into the gastrointesti...

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Bibliographic Details
Published in:Core Evid
Main Authors: Takatsu, Noritaka, Hisabe, Takashi, Higashi, Daijiro, Ueki, Toshiharu, Matsui, Toshiyuki
Format: Artigo
Language:Inglês
Published: Dove 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7131995/
https://ncbi.nlm.nih.gov/pubmed/32280316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CE.S179053
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