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Intranasal administration of IL-35 inhibits allergic responses and symptoms in mice with allergic rhinitis

BACKGROUND: IL-35 was recently identified as an anti-inflammatory cytokine. We previously reported that recombinant fusion protein of murine IL-35 and human IgG1 Fc fragment (rIL-35) reduced Th2 cytokines (IL-4 and IL-5) in vitro. However, it is unclear whether IL-35 can attenuate nasal allergic res...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Allergol Int
Hauptverfasser: Suzuki, Motohiko, Yokota, Makoto, Nakamura, Yoshihisa, Ozaki, Shinya, Murakami, Shingo
Format: Artigo
Sprache:Inglês
Veröffentlicht: , Japanese Society of Allergology. Production and hosting by Elsevier B.V. 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7130026/
https://ncbi.nlm.nih.gov/pubmed/27707583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.alit.2016.08.014
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