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Intranasal administration of IL-35 inhibits allergic responses and symptoms in mice with allergic rhinitis

BACKGROUND: IL-35 was recently identified as an anti-inflammatory cytokine. We previously reported that recombinant fusion protein of murine IL-35 and human IgG1 Fc fragment (rIL-35) reduced Th2 cytokines (IL-4 and IL-5) in vitro. However, it is unclear whether IL-35 can attenuate nasal allergic res...

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Detalhes bibliográficos
Publicado no:Allergol Int
Principais autores: Suzuki, Motohiko, Yokota, Makoto, Nakamura, Yoshihisa, Ozaki, Shinya, Murakami, Shingo
Formato: Artigo
Idioma:Inglês
Publicado em: , Japanese Society of Allergology. Production and hosting by Elsevier B.V. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7130026/
https://ncbi.nlm.nih.gov/pubmed/27707583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.alit.2016.08.014
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