Apoptosis induced by a cytopathic hepatitis A virus is dependent on caspase activation following ribosomal RNA degradation but occurs in the absence of 2′–5′ oligoadenylate synthetase

We have presented previously evidence that the cytopathogenic 18f strain of hepatitis A virus (HAV) induced degradation of ribosomal RNA (rRNA) in infected cells [Arch. Virol. 148 (2003) 1275–1300]. In contrast, the non-cytopathogenic parent virus HM175 clone 1 had no effect on rRNA integrity. We pr...

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Veröffentlicht in:Antiviral Res
Hauptverfasser: Goswami, Biswendu B., Kulka, Michael, Ngo, Diana, Cebula, Thomas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127220/
https://ncbi.nlm.nih.gov/pubmed/15451183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2004.02.004
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