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Temperature-sensitive mutants of mouse hepatitis virus strain A59: Isolation, characterization and neuropathogenic properties

Twenty 5-fluorouracil-induced temperature-sensitive (ts) mutants of mouse hepatitis virus strain A59 were isolated from 1284 virus clones. Mutants were preselected on the basis of their inability to induce syncytia in infected cells at the restrictive temperature (40°) vs the permissive temperature...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Koolen, Marck J.M., Osterhaus, Albert D.M.E., Van Steenis, Gijsbert, Horzinek, Marian C., van der Zeijst, Bernard A.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Published by Elsevier Inc. 1983
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7126919/
https://ncbi.nlm.nih.gov/pubmed/6301146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/0042-6822(83)90211-8
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