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Temperature-sensitive mutants of mouse hepatitis virus strain A59: Isolation, characterization and neuropathogenic properties

Twenty 5-fluorouracil-induced temperature-sensitive (ts) mutants of mouse hepatitis virus strain A59 were isolated from 1284 virus clones. Mutants were preselected on the basis of their inability to induce syncytia in infected cells at the restrictive temperature (40°) vs the permissive temperature...

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Publicado en:Virology
Autores principales: Koolen, Marck J.M., Osterhaus, Albert D.M.E., Van Steenis, Gijsbert, Horzinek, Marian C., van der Zeijst, Bernard A.M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Published by Elsevier Inc. 1983
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7126919/
https://ncbi.nlm.nih.gov/pubmed/6301146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/0042-6822(83)90211-8
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