5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties

Synthetically combining the C-4′ side-chain structural features of the antiviral candidates 5′-methylaristeromycin and 5′-homoaristeromycin into a diastereomeric pair of C-4′ side-chain dihydroxylated aristeromycins (6 and 7) is reported. Broad antiviral analyses of the both targets found promising...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Chen, Qi, Liu, Chong, Bowlin, Terry L., Schneller, Stewart W.
Format: Artigo
Language:Inglês
Published: Elsevier Ltd. 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7126772/
https://ncbi.nlm.nih.gov/pubmed/29628328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.03.088
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