Targeting of radioactive platinum-bisphosphonate anticancer drugs to bone of high metabolic activity

Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance, and lack of tumor selectivity. Tumor-targeted drug delivery has demonstrated great potential to overcome these drawbacks. Herein, we aimed to d...

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Publicado en:Sci Rep
Autores principales: Nadar, Robin A., Farbod, Kambiz, der Schilden, Karlijn Codee-van, Schlatt, Lukas, Crone, Barbara, Asokan, Nandini, Curci, Alessandra, Brand, Michael, Bornhaeuser, Martin, Iafisco, Michele, Margiotta, Nicola, Karst, Uwe, Heskamp, Sandra, Boerman, Otto C., van den Beucken, Jeroen J. J. P., Leeuwenburgh, Sander C. G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125202/
https://ncbi.nlm.nih.gov/pubmed/32246003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62039-2
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