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Comprehensive sequence-to-function mapping of cofactor-dependent RNA catalysis in the glmS ribozyme
Massively parallel, quantitative measurements of biomolecular activity across sequence space can greatly expand our understanding of RNA sequence-function relationships. We report the development of an RNA-array assay to perform such measurements and its application to a model RNA: the core glmS rib...
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| Vydáno v: | Nat Commun |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7125110/ https://ncbi.nlm.nih.gov/pubmed/32245964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15540-1 |
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