Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses

The NF-κB and interferon antiviral signaling pathways play pivotal roles in inflammatory and innate immune responses. The LUBAC ubiquitin ligase complex, composed of the HOIP, HOIL-1L, and SHARPIN subunits, activates the canonical NF-κB pathway through Met1-linked linear ubiquitination. We identifie...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Oikawa, Daisuke, Sato, Yusuke, Ohtake, Fumiaki, Komakura, Keidai, Hanada, Kazuki, Sugawara, Koji, Terawaki, Seigo, Mizukami, Yukari, Phuong, Hoang T., Iio, Kiyosei, Obika, Shingo, Fukushi, Masaya, Irie, Takashi, Tsuruta, Daisuke, Sakamoto, Shinji, Tanaka, Keiji, Saeki, Yasushi, Fukai, Shuya, Tokunaga, Fuminori
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125101/
https://ncbi.nlm.nih.gov/pubmed/32246052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0882-8
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