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Intracerebral expression of AAV-APOE4 is not sufficient to alter tau burden in two distinct models of tauopathy
Apolipoprotein E4 (APOE4) is the major genetic risk factor for sporadic Alzheimer’s disease (AD), which is characterized by amyloid β (Aβ) plaques and tau tangles. Though the role of APOE4 in Aβ pathogenesis has been mechanistically defined in rodent models, much less is known regarding the relation...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Mol Neurobiol |
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| Κύριοι συγγραφείς: | , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7125036/ https://ncbi.nlm.nih.gov/pubmed/31903524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-01859-4 |
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