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Targeted deletion of Cyp1b1 in pericytes results in attenuation of retinal neovascularization and trabecular meshwork dysgenesis

Mutations in cytochrome P450 1B1 (CYP1B1) gene are reported in patients with primary congenital glaucoma. Cyp1b1-deficient (Cyp1b1−/−) mice show dysgenesis of the trabecular meshwork (TM) tissue and attenuation of retinal neovascularization during oxygen-induced ischemic retinopathy (OIR). Although...

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發表在:Trends Dev Biol
Main Authors: Falero-Perez, Juliana, Larsen, Michele C., Teixeira, Leandro B. C., Zhang, Hao F., Lindner, Volkhard, Sorenson, Christine M., Jefcoate, Colin R., Sheibani, Nader
格式: Artigo
語言:Inglês
出版: 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7120807/
https://ncbi.nlm.nih.gov/pubmed/32255961
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