Ross River virus envelope glycans contribute to disease through activation of the host complement system

Mannose binding lectin (MBL) generally plays a protective role during viral infection, yet MBL-mediated complement activation promotes Ross River virus (RRV)-induced inflammatory tissue destruction, contributing to arthritis and myositis. As MBL binds to carbohydrates, we hypothesized that N-linked...

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Foilsithe in:Virology
Main Authors: Gunn, Bronwyn M., Jones, Jennifer E., Shabman, Reed S., Whitmore, Alan C., Sarkar, Sanjay, Blevins, Lance K., Morrison, Thomas E., Heise, Mark T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Published by Elsevier Inc. 2018
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7119116/
https://ncbi.nlm.nih.gov/pubmed/29324290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.12.022
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