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Increased Osteoclast and Decreased Osteoblast Activity Causes Reduced Bone Mineral Density and Quality in Genetic Hypercalciuric Stone‐Forming Rats

To study human idiopathic hypercalciuria (IH), we developed an animal model, genetic hypercalciuric stone‐forming (GHS) rats, whose pathophysiology parallels that in IH. All GHS rats form kidney stones and have decreased BMD and bone quality compared with the founder Sprague–Dawley (SD) rats. To und...

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Détails bibliographiques
Publié dans:JBMR Plus
Auteurs principaux: Krieger, Nancy S, Chen, Luojing, Becker, Jennifer, DeBoyace, Sean, Wang, Hongwei, Favus, Murray J, Bushinsky, David A
Format: Artigo
Langue:Inglês
Publié: John Wiley & Sons, Ltd 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7117851/
https://ncbi.nlm.nih.gov/pubmed/32258968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10350
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