Genetic deletion of Autotaxin from CD11b(+) cells decreases the severity of experimental autoimmune encephalomyelitis

Autotaxin (ATX) is a secreted lysophospholipase D catalyzing the extracellular production of lysophosphatidic acid (LPA), a growth factor-like signaling lysophospholipid. ATX and LPA signaling have been incriminated in the pathogenesis of different chronic inflammatory diseases and various types of...

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Bibliographic Details
Published in:PLoS One
Main Authors: Ninou, Ioanna, Sevastou, Ioanna, Magkrioti, Christiana, Kaffe, Eleanna, Stamatakis, George, Thivaios, Spyros, Panayotou, George, Aoki, Junken, Kollias, George, Aidinis, Vassilis
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7117669/
https://ncbi.nlm.nih.gov/pubmed/32240164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226050
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