Escherichia coli RhoGTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21 activated kinases-1/2 during bacteremia in mice

Inflammasomes are signaling platforms that are assembled in response to infection or sterile inflammation by cytosolic pattern recognition receptors (PRRs). The consequent inflammasome-triggered Caspase-1 activation is critical for the host defense against pathogens. During infection, NLRP3, a PRR a...

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Publicado no:Nat Microbiol
Main Authors: Dufies, Océane, Doye, Anne, Courjon, Johan, Torre, Cédric, Michel, Gregory, Loubatier, Celine, Jacquel, Arnaud, Chaintreuil, Paul, Majoor, Alissa, Guinamard, Rodolphe R., Gallerand, Alexandre, Saavedra, Pedro H. V., Verhoeyen, Els, Rey, Amaury, Marchetti, Sandrine, Ruimy, Raymond, Czerucka, Dorota, Lamkanfi, Mohamed, Py, Bénédicte F., Munro, Patrick, Visvikis, Orane, Boyer, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116836/
https://ncbi.nlm.nih.gov/pubmed/33432150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-00832-5
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