Lipid nanoparticle mediated siRNA delivery for safe targeting of human CML in vivo

Efficient and safe delivery of siRNA in vivo is the biggest roadblock to clinical translation of RNA interference (RNAi) based therapeutics. To date, lipid nanoparticles (LNPs) have shown efficient delivery of siRNA to the liver; however, delivery to other organs, especially hematopoietic tissues st...

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Detalhes bibliográficos
Publicado no:Ann Hematol
Main Authors: Jyotsana, Nidhi, Sharma, Amit, Chaturvedi, Anuhar, Budida, Ramachandramouli, Scherr, Michaela, Kuchenbauer, Florian, Lindner, Robert, Noyan, Fatih, Sühs, Kurt-Wolfram, Stangel, Martin, Grote-Koska, Denis, Brand, Korbinian, Vornlocher, Hans-Peter, Eder, Matthias, Thol, Felicitas, Ganser, Arnold, Humphries, R. Keith, Ramsay, Euan, Cullis, Pieter, Heuser, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116733/
https://ncbi.nlm.nih.gov/pubmed/31104089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00277-019-03713-y
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