Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage

OBJECTIVE: After aneurysmal subarachnoid haemorrhage (aSAH), extracellular haemoglobin (Hb) in the subarachnoid space is bound by haptoglobin, neutralizing Hb toxicity and helping its clearance. Two exons in the HP gene (encoding haptoglobin) exhibit copy number variation (CNV), giving rise to HP1 a...

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Publicado no:J Neurol Neurosurg Psychiatry
Main Authors: Morton, Matthew J, Hostettler, Isabel C, Kazmi, Nabila, Alg, Varinder, Bonner, Stephen, Brown, Martin M, Durnford, Andrew, Gaastra, Ben, Garland, Patrick, Grieve, Joan, Kitchen, Neil, Walsh, Daniel, Zolnourian, Ardalan, Houlden, Henry, Gaunt, Tom R, Bulters, Diederik, Werring, David J, Galea, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116595/
https://ncbi.nlm.nih.gov/pubmed/31937585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2019-321697
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