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Human CNS barrier-forming organoids with cerebrospinal fluid production

Cerebrospinal fluid (CSF) is a vital liquid, providing nutrients, signalling molecules, and clearing out toxic byproducts from the brain. The CSF is produced by the choroid plexus (ChP), a protective epithelial barrier that also prevents free entry from the blood. Here, we establish human ChP organo...

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Détails bibliographiques
Publié dans:Science
Auteurs principaux: Pellegrini, Laura, Bonfio, Claudia, Chadwick, Jessica, Begum, Farida, Skehel, Mark, Lancaster, Madeline A.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116154/
https://ncbi.nlm.nih.gov/pubmed/32527923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz5626
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