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Functional Impact of the G279S Substitution in the Adenosine A(1)-Receptor (A(1)R-G279S(7.44)), a Mutation Associated with Parkinson’s Disease
In medium-size, spiny striatal neurons of the direct pathway, dopamine D(1)- and adenosine A(1)-receptors are coexpressed and are mutually antagonistic. Recently, a mutation in the gene encoding the A(1)-receptor (A(1)R), A(1)R-G279S(7.44), was identified in an Iranian family: two affected offspring...
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| Publicado en: | Mol Pharmacol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7116137/ https://ncbi.nlm.nih.gov/pubmed/32817461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.120.000003 |
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