Altered pathogenicity, immunogenicity, tissue tropism and 3′-7 kb region sequence of an avian infectious bronchitis coronavirus strain after serial passage in embryos

In this study, we attenuated a Chinese LX4-type nephropathogenic infectious bronchitis virus (IBV) strain, CK/CH/LHLJ/04V, by serial passage in embryonated chicken eggs. Based on sequence analysis of the 3′-7 kb region, the CK/CH/LHLJ/04V virus population contained subpopulations with a mixture of g...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Liu, Shengwang, Zhang, Xiaonan, Gong, Liyang, Yan, Baolong, Li, Chengren, Han, Zongxi, Shao, Yuhao, Li, Huixin, Kong, Xiangang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115700/
https://ncbi.nlm.nih.gov/pubmed/19523910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.05.072
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