Inactivated or damaged? Comparing the effect of inactivation methods on influenza virions to optimize vaccine production

The vast majority of commercially available inactivated influenza vaccines are produced from egg-grown or cell-grown live influenza virus. The first step in the production process is virus inactivation with β-propiolactone (BPL) or formaldehyde (FA). Recommendations for production of inactivated vac...

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Bibliographic Details
Published in:Vaccine
Main Authors: Herrera-Rodriguez, José, Signorazzi, Aurora, Holtrop, Marijke, de Vries-Idema, Jacqueline, Huckriede, Anke
Format: Artigo
Language:Inglês
Published: The Author(s). Published by Elsevier Ltd. 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115651/
https://ncbi.nlm.nih.gov/pubmed/30765167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2019.01.086
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