Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor

We report the synthesis and antiviral activity of a new family of non-nucleoside antivirals, derived from the indole nucleus. Modifications of this template through Mannich and Friedel-Crafts reactions, coupled with nucleophilic displacement and reductive aminations led to 23 final derivatives, whic...

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Bibliografiske detaljer
Udgivet i:Eur J Med Chem
Main Authors: Musella, Simona, di Sarno, Veronica, Ciaglia, Tania, Sala, Marina, Spensiero, Antonia, Scala, Maria Carmina, Ostacolo, Carmine, Andrei, Graciela, Balzarini, Jan, Snoeck, Robert, Novellino, Ettore, Campiglia, Pietro, Bertamino, Alessia, Gomez-Monterrey, Isabel M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Masson SAS. 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115581/
https://ncbi.nlm.nih.gov/pubmed/27639368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.09.014
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