Intranasal immunization with inactivated SARS-CoV (SARS-associated coronavirus) induced local and serum antibodies in mice

SARS-CoV (severe acute respiratory syndrome-associated coronavirus) strain GZ50 was partially purified and inactivated with 1:2000 formaldehyde. In cell culture the inactivated virus blocked the replication of live virus by decreasing the TCID(5.0) of the live virus 10(3.6) to 10(4.6) times. Inactiv...

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Publicado en:Vaccine
Autores principales: Qu, Di, Zheng, Bojian, Yao, Xin, Guan, Yi, Yuan, Zheng-Hong, Zhong, Nan-Shan, Lu, Li-Wei, Xie, Jian-Ping, Wen, Yu-Mei
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Ltd. 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115388/
https://ncbi.nlm.nih.gov/pubmed/15603894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2004.07.031
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