Higher proteotoxic stress rather than mitochondrial damage is involved in higher neurotoxicity of bortezomib compared to carfilzomib

Proteasome inhibitors have great success for their therapeutic potential against hematologic malignancies. First generation proteasome inhibitor bortezomib induced peripheral neuropathy is considered as a limiting factor in chemotherapy and its second-generation counterpart carfilzomib is associated...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Jannuzzi, Ayse Tarbin, Arslan, Sema, Yilmaz, Ayse Mine, Sari, Gulce, Beklen, Hande, Méndez, Lucía, Fedorova, Maria, Arga, Kazim Yalcin, Karademir Yilmaz, Betul, Alpertunga, Buket
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115161/
https://ncbi.nlm.nih.gov/pubmed/32244176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101502
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