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Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan
Deciphering molecular targets to enhance sensitivity to chemotherapy is becoming a priority for effectively treating cancers. Loss of function mutations of SMAD4 in colon cancer is associated with metastatic progression and resistance to 5-fluorouracil (5-FU), the most extensively used drug of almos...
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| Publicat a: | Mol Cancer Res |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7115128/ https://ncbi.nlm.nih.gov/pubmed/31932471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0525 |
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