Mutation in the cytoplasmic retrieval signal of porcine epidemic diarrhea virus spike (S) protein is responsible for enhanced fusion activity

Murine-adapted porcine epidemic diarrhea virus (PEDV), MK-p10, shows high neurovirulence and increased fusion activity compared with a non-adapted MK strain. MK-p10 S protein had four mutations relative to the original virus S, and one of these (H → R at position 1381, H1381R) in the cytoplasmic tai...

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Detalhes bibliográficos
Publicado no:Virus Res
Main Authors: Shirato, Kazuya, Maejima, Madoka, Matsuyama, Shutoku, Ujike, Makoto, Miyazaki, Ayako, Takeyama, Natsumi, Ikeda, Hidetoshi, Taguchi, Fumihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2011
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114372/
https://ncbi.nlm.nih.gov/pubmed/21840351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2011.07.019
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