Comparative Molecular Dynamics Simulations Provide Insight Into Antibiotic Interactions: A Case Study Using the Enzyme L,L-Diaminopimelate Aminotransferase (DapL)

The L,L-diaminopimelate aminotransferase (DapL) pathway, a recently discovered variant of the lysine biosynthetic pathway, is an attractive pipeline to identify targets for the development of novel antibiotic compounds. DapL is a homodimer that catalyzes the conversion of tetrahydrodipicolinate to L...

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Bibliographic Details
Published in:Front Mol Biosci
Main Authors: Adams, Lily E., Rynkiewicz, Patrick, Babbitt, Gregory A., Mortensen, Jamie S., North, Rachel A., Dobson, Renwick C. J., Hudson, André O.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Molecular Biosciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113581/
https://ncbi.nlm.nih.gov/pubmed/32274387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00046
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