Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms

Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. However, detailed molecular mechanisms of ALK1-mediated signalling remain unclear. Here, we repor...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Salmon, Richard M., Guo, Jingxu, Wood, Jennifer H., Tong, Zhen, Beech, John S., Lawera, Aleksandra, Yu, Minmin, Grainger, David J., Reckless, Jill, Morrell, Nicholas W., Li, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113306/
https://ncbi.nlm.nih.gov/pubmed/32238803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15425-3
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