B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response

Activation-induced cytidine deaminase (AID) mediates immunoglobulin class switch DNA recombination (CSR) and somatic hypermutation (SHM), critical processes for maturation of the antibody response. Epigenetic factors, such as histone deacetylases (HDACs), would underpin B cell differentiation stage–...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Adv
Egile Nagusiak: Gan, Huoqun, Shen, Tian, Chupp, Daniel P., Taylor, Julia R., Sanchez, Helia N., Li, Xin, Xu, Zhenming, Zan, Hong, Casali, Paolo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Association for the Advancement of Science 2020
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112761/
https://ncbi.nlm.nih.gov/pubmed/32270032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay2793
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