IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection

In the skin, antiviral proteins and other immune molecules serve as the first line of innate antiviral defense. Here, we identify and characterize the induction of cutaneous innate antiviral proteins in response to IL-27 and its functional role during cutaneous defense against Zika virus infection....

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Kwock, Jeffery T., Handfield, Chelsea, Suwanpradid, Jutamas, Hoang, Peter, McFadden, Michael J., Labagnara, Kevin F., Floyd, Lauren, Shannon, Jessica, Uppala, Ranjitha, Sarkar, Mrinal K., Gudjonsson, Johann E., Corcoran, David L., Lazear, Helen M., Sempowski, Gregory, Horner, Stacy M., MacLeod, Amanda S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112749/
https://ncbi.nlm.nih.gov/pubmed/32270034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay3245
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