Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L

Priming of the viral glycoprotein (GP) by the cellular proteases cathepsin B and L (CatB, CatL) is believed to be essential for cell entry of filoviruses. However, pseudotyping systems that predominantly produce non-filamentous particles have frequently been used to prove this concept. Here, we repo...

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Bibliographic Details
Published in:Virology
Main Authors: González-Hernández, Mariana, Müller, Andreas, Hoenen, Thomas, Hoffmann, Markus, Pöhlmann, Stefan
Format: Artigo
Language:Inglês
Published: Published by Elsevier Inc. 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112014/
https://ncbi.nlm.nih.gov/pubmed/30999160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.03.020
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