An arginine-to-proline mutation in a domain with undefined functions within the helicase protein (Nsp13) is lethal to the coronavirus infectious bronchitis virus in cultured cells

Genetic manipulation of the RNA genomes by reverse genetics is a powerful tool to study the molecular biology and pathogenesis of RNA viruses. During construction of an infectious clone from a Vero cell-adapted coronavirus infectious bronchitis virus (IBV), we found that a G–C point mutation at nucl...

Full description

Saved in:
Bibliographic Details
Published in:Virology
Main Authors: Fang, Shouguo, Chen, Bo, Tay, Felicia P.L., Ng, Beng Sern, Liu, Ding Xing
Format: Artigo
Language:Inglês
Published: Elsevier Inc. 2007
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111978/
https://ncbi.nlm.nih.gov/pubmed/16979681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.08.020
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items